Endocrine Abstracts

Anemia occurs early and predicts high risk of cardiovascular events and death in patients with diabetic nephropathy (DN). It results from various factors including erythropoietin (EPO) deficiency and inflammation. The aim of this study was to evaluate clinical correlates of TNF alpha levels in anemic patients with early diabetic nephropathy. We investigated 95 anemic patients with type 2 diabetes mellitus and chronic kidney disease (stages 1–3). Glomerular filtration rate...

Anemia occurs early and predicts high risk of cardiovascular events and death in patients with diabetic nephropathy (DN). It results from various factors including erythropoietin (EPO) deficiency and inflammation. The aim of this study was to evaluate clinical correlates of TNF alpha levels in anemic patients with early diabetic nephropathy. We investigated 95 anemic patients with type 2 diabetes mellitus and chronic kidney disease (stages 1–3). Glomerular filtration rate...

Aims: Anaemia occurs early and predicts high risk of cardiovascular events and death in patients with diabetic nephropathy. In our previous studies we have shown that haemoglobin level has a negative correlation with serum levels of proinflammatory cytokines in this clinical group. It could be hypothesised that treatment of anaemia has anti-inflammatory effects. The aim of this study was to assess the influence of treatment with erythropoietin alpha on serum level of tumour ne...

Introduction: Anemia is associated with an increased risk of cardiovascular events and death in patients with diabetic nephropathy (DN). However, there are still a lot of contradictions related to the benefits and risks of antianemic treatment in this group of patients due to variety of non-hematopoietic effects of erythropoietin. The aim of this study was to assess the influence of erythropoietin therapy on renal function and proteinuria in patients with early DN.<p class...

Background and Aim: To study the cardioprotective effects of empagliflozin and vildagliptin in patients with diabetes type 2.Method: 90 patients with type 2 diabetes were randomized using a random number generator into 3 groups, depending on the antihyperglycemic therapy prescribed for the next 6 months: the group that continued to receive gliclazide and metformin, the group in addition to gliclazide and metformin received vildagliptin at a dose of 100 m...

There is growing evidence that platelet indices correlate with functional status of platelets and with the risk of cardiovascular events. In this study we aimed to assess clinical correlates of mean platelet volume (MPV) in patients with abdominal obesity from different age groups. We investigated 111 adults with abdominal obesity, not receiving antiplatelet therapy. Abdominal obesity was defined in accordance with IDF criteria (2006). Group 1 included 44 patients aged 26&#150...

Background and Aims: to assess the relationship between level of interleukin-6 (IL-6) and the renal function in patients with diabetes mellitus (DM).Method: A total of 416 patients with DM, aged 34 to 75 years, were examined. Control group included 60 healthy patients the same age/All patients underwent standard clinical and laboratory examination, with an assessment of the levels of natriuretic peptides (BNP, proBNP) and level of IL-6. Renal function wa...

Aims: Anemia occurs early and predicts high risk of cardiovascular events and death in patients with diabetic nephropathy. The aim of this study was to assess the influence of anemia on the quality of life of patients with early diabetic nephropathy.Methods: We investigated 95 anemic and 32 non-anemic patients with type 2 diabetes mellitus and early diabetic nephropathy (CKD stages 1–3). Anemia was defined according to WHO criteria. Anemic patients ...

Proinflammmatory cytokines including interferon gamma (IFNg) are known to be involved in the pathogenesis of diabetic nephropathy. The aim of this study was to assess serum level of IFNg and its clinical correlates in patients with type 2 diabetes and early CKD receiving different types of treatment. We investigated 64 patients with type 2 diabetes and CKD stages 1-3. Group 1 included 20 patients on insulin therapy. Group 2 included 44 patients on metformin or combined oral hy...

Objective: Cystatin C has been proposed as a novel marker of renal function and as a predictor of the severity of coronary atherosclerosis and future cardiovascular events. The aim was to evaluate the possible role of chronic kidney disease and particularly CysC on the characteristics of carotid atherosclerosis in patients with type 2 diabetes (DT2).Materials and methods: We investigated 195 patients both sexes with DT2 aged 56.54±4.17 years. Contro...